Analysis of genetic aberrations in pediatric high-grade gliomas
نویسندگان
چکیده
منابع مشابه
A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.
PURPOSE As genome-scale technologies begin to unravel the complexity of the equivalent tumors in adults, we can attempt detailed characterization of high-grade gliomas in children, that have until recently been lacking. Toward this end, we sought to validate and extend investigations of the differences between pediatric and adult tumors. EXPERIMENTAL DESIGN We carried out copy number profilin...
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BACKGROUND High-grade gliomas (HGGs) account for 15% of all pediatric brain tumors and are a leading cause of cancer-related mortality and morbidity. Pediatric HGGs (pHGGs) are histologically indistinguishable from their counterpart in adulthood. However, recent investigations indicate that differences occur at the molecular level, thus suggesting that the molecular path to gliomagenesis in chi...
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The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor α (PDGFRA) is the most frequent target of f...
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BACKGROUND Glioma is a type of tumor that develops in the central nerve system, mainly the brain. Alterations of genomic sequence and sequence segments (such as copy number variations or CNV and copy neutral loss of heterozygosities or cnLOH) are thought to be a major determinant of the tumor grade. METHODS We mapped genomic variations between low-grade and high-grade gliomas (LGG and HGG) in...
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ژورنال
عنوان ژورنال: Advances in Molecular Oncology
سال: 2020
ISSN: 2413-3787,2313-805X
DOI: 10.17650/2313-805x-2020-7-3-37-47